Is nitrofurantoin contraindicated in late pregnancy, and if so, why?

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Prepare for the Anti-infective Medications Test with comprehensive multiple-choice questions and explanations. Dive into study materials and enhance your understanding to succeed in your exam!

Multiple Choice

Is nitrofurantoin contraindicated in late pregnancy, and if so, why?

Explanation:
Late in pregnancy, nitrofurantoin is avoided because of the risk of neonatal hemolytic anemia. The drug can cross the placenta, and newborn red blood cells, especially in those with G6PD deficiency, have limited capacity to handle oxidative stress. Nitrofurantoin can provoke hemolysis in these infants, leading to anemia and jaundice after birth. This is why it’s contraindicated near term. It does not cause neural tube defects or preterm labor, and it isn’t considered safe at all stages of pregnancy.

Late in pregnancy, nitrofurantoin is avoided because of the risk of neonatal hemolytic anemia. The drug can cross the placenta, and newborn red blood cells, especially in those with G6PD deficiency, have limited capacity to handle oxidative stress. Nitrofurantoin can provoke hemolysis in these infants, leading to anemia and jaundice after birth. This is why it’s contraindicated near term. It does not cause neural tube defects or preterm labor, and it isn’t considered safe at all stages of pregnancy.

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