Penicillin G is never given by which route?

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Prepare for the Anti-infective Medications Test with comprehensive multiple-choice questions and explanations. Dive into study materials and enhance your understanding to succeed in your exam!

Multiple Choice

Penicillin G is never given by which route?

Explanation:
Penicillin G is acid-labile, meaning it is destroyed by stomach acid and is poorly absorbed when given by mouth. This makes oral administration unreliable for achieving therapeutic blood levels, so it is never given per os. To treat infections effectively, Penicillin G is administered parenterally—usually intravenously for rapid, reliable levels or intramuscularly for certain indications. In contrast, penicillin V is the oral form that can be used when an oral route is acceptable because it remains stable in gastric acid and is absorbed better.

Penicillin G is acid-labile, meaning it is destroyed by stomach acid and is poorly absorbed when given by mouth. This makes oral administration unreliable for achieving therapeutic blood levels, so it is never given per os. To treat infections effectively, Penicillin G is administered parenterally—usually intravenously for rapid, reliable levels or intramuscularly for certain indications. In contrast, penicillin V is the oral form that can be used when an oral route is acceptable because it remains stable in gastric acid and is absorbed better.

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