Two major safety concerns associated with fluoroquinolones?

• A. CNS effects and photosensitivity
• B. Tendon rupture risk and QT prolongation
• C. Hepatotoxicity and ototoxicity
• D. Hyperkalemia and anemia

Answer: (B)

Two major safety concerns with fluoroquinolones are tendon damage and heart rhythm problems. These antibiotics can weaken tendons and increase the risk of tendinopathy or tendon rupture, especially in people over 60, those taking corticosteroids, or with certain health conditions. This makes tendon issues a standout safety priority with this drug class.

They can also prolong the QT interval on an ECG, which raises the risk of serious arrhythmias like torsades de pointes. The risk is higher with certain agents and when there are electrolyte disturbances or other QT-prolonging drugs involved.

Other adverse effects, such as CNS effects or photosensitivity, can occur but are less emphasizing of safety concerns compared with tendon rupture and QT prolongation. Hepatotoxicity and ototoxicity are less common and not as central to fluoroquinolone safety as the two main issues discussed.